تفاعل #4387

معادلة التفاعل

2-amino-3-hydroxypyridine

2-methylbenzyl chloride

→

2-amino-3-(2-methylbenzyloxy)pyridine

المذيبات

sodium hydroxide

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   أخرىthe organic layer was separated
2. 2
   استخلاصthe aqueous layer was extracted with methylene chloride
3. 3
   غسيلThe combined extracts were washed with saturated sodium chloride aqueous solution
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   أخرىevaporated in vacuo
6. 6
   أخرىThe crystalline residue was recrystallized from ethyl acetate

الإجراء التجريبي

To a mixture of 2-amino-3-hydroxypyridine (7 g) and Adogen 464 (Trademark: prepared by Aldrich Chemical Co.) (0.4 g) in 40% aqueous sodium hydroxide (32 ml) and methylene chloride (32 ml) was added 2-methylbenzyl chloride (8.42 ml) at ambient temperature. After being stirred for 24 hours, the organic layer was separated and the aqueous layer was extracted with methylene chloride. The combined extracts were washed with saturated sodium chloride aqueous solution, dried over magnesium sulfate, and evaporated in vacuo. The crystalline residue was recrystallized from ethyl acetate to give 2-amino-3-(2-methylbenzyloxy)pyridine (7.56 g).

المصدر