تفاعل #43867

معادلة التفاعل

{5-[Benzyl-(3-chloro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

TFA

→

title compound

{5-[Benzyl-(3 -chloro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   أخرىpurified by preparative LCMS

الإجراء التجريبي

{5-[Benzyl-(3-chloro-benzoyl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester (0.12 mmol) was treated with TFA (2 mL) for 2 hours, concentrated, and purified by preparative LCMS to give the title compound. 1H NMR (d6-DMSO) δ7.89 (m, 1H), 7.71 (m, 1H), 7.52 (m, 1H), 7.45 (m, 1H), 7.21 (m, 6H), 6.91 (m, 1H), 5.11 (s, 2H), 4.91 (s, 2H), 2.65 (t, 2H), 1.71 (m, 2H), 0.92 (t, 3H). MS calculated for C26H24ClN3O3+H: 462, observed: 462.

المصدر