تفاعل #43861

معادلة التفاعل

{5-[Benzyl-(3-methyl-butyryl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester

TFA

→

title compound

{5-[Benzyl-(3-methyl-butyryl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid

ظروف التفاعل

المعالجة

1. 1
   تركيزconcentrated
2. 2
   أخرىpurified by preparative LCMS

الإجراء التجريبي

{5-[Benzyl-(3-methyl-butyryl)-amino]-2-propyl-benzoimidazol-1-yl}-acetic acid tert-butyl ester (0.12 mmol) was treated with TFA (2 mL) for 2 hours, concentrated, and purified by preparative LCMS to give the title compound. 1H NMR (d6-DMSO) δ7.48 (d, 1H), 7.21 (m, 6H), 6.92 (m, 1H), 5.08 (s, 2H), 4.89 (s, 2H), 2.72 (t, 2H), 2.00 (m, 3H), 1.71 (m, 2H), 0.99 (t, 3H), 0.79 (m, 6H). MS calculated for C24H29N3O3+H: 408, observed: 408.

المصدر