تفاعل #43856

معادلة التفاعل

Acetyl chloride

(5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

DIEA

→

subtitle compound

[5-(Acetyl-benzyl-amino)-2-propyl-benzoimidazol-1-yl]-acetic acid tert-butyl ester

المذيبات

HCl

CH2Cl2

ظروف التفاعل

المعالجة

1. 1
   ترشيحfiltered through an Extrelut column
2. 2
   غسيلThe Extrelut column was washed with CH2Cl2
3. 3
   تركيزthe filtrate was concentrated

الإجراء التجريبي

Acetyl chloride (25 μL, 0.36 mmol) was added to a solution of (5-benzylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester (45 mg, 0.12 mmol), DIEA (41 μL, 0.24 mmol) and DMAP (15 mg, 0.12 mmol) in CH2Cl2 (1 mL), and stirred overnight at room temperature. The reaction solution was diluted with aqueous HCl (1.0 M) and filtered through an Extrelut column. The Extrelut column was washed with CH2Cl2, and the filtrate was concentrated to afford the subtitle compound that was used without further purification. MS calculated for C25H31N3O3+H: 422, observed: 422.

المصدر