تفاعل #438486
ord-5f92f863da7b42ef84344f9dca9f82b5
معادلة التفاعل
2,2,2-Trifluoroacetophenone
L-leucine ethyl ester
K2CO3
→
title compound
N-(2,2,2-TRIFLUORO-1-PHENYLETHYLIDENE)-L-LEUCINE POTASSIUM SALT
الكواشف
لا شيء
المذيبات
ظروف التفاعل
درجة الحرارة
50°CELSIUS
الظروف التفصيلية
See reaction.notes.procedure_details.
المعالجة
- 1درجة الحرارةThe mixture was cooled to 20–25° C.
- 2ترشيحfiltered
- 3تركيزconcentrated
- 4ترشيحfiltered
الإجراء التجريبي
2,2,2-Trifluoroacetophenone (4.24 g, 24.3 mmol) was added to a mixture of L-leucine ethyl ester (3.52 g, 22.1 mmol) and K2CO3 (2.90 g, 20.9 mmol) in MeOH (50 mL). The mixture was warmed to 50° C. for 18 h. The mixture was cooled to 20–25° C., filtered and concentrated. The residue was suspended in TBME (100 ml) and filtered to give the title compound as a white solid.