تفاعل #437798

معادلة التفاعل

HCl

2-cyano-acetanilide

tri-n-butyltin azide

→

2-(1H-tetrazol-5-yl)acetanilide

المردود 90.3%

المذيبات

Et2O

toluene

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 48 hrs
2. 2
   أخرىThe resulting precipate was collected by suction
3. 3
   غسيلwashed with hexane
4. 4
   أخرىdried in vacuo

الإجراء التجريبي

A solution of 2-cyano-acetanilide (0.801 g, 5.0 mmol) and tri-n-butyltin azide (2.05 mL, 7.5 mmol) in anhydrous toluene (10 mL) was heated at reflux for 48 hrs. The mixture was allowed to cool to room temperature and treated with 2.0 N HCl in Et2O (5.0 mL). The resulting precipate was collected by suction, washed with hexane and dried in vacuo to give 2-(1H-tetrazol-5-yl)acetanilide (0.917 g, 90%) as a white solid.

المصدر