تفاعل #4377

معادلة التفاعل

iodine

1-(3-methoxyphenyl)butane-3-one

→

1-(2-iodo-5-methoxyphenyl)butane-3-one

المردود 82.3%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   أخرىThe silver iodide was removed by filtration
2. 2
   غسيلwashed with acetic acid
3. 3
   أخرىThe filtrate was partitioned between ether and water
4. 4
   غسيلThe ether layer was washed with water, sodium bicarbonate solution and sodium thiosulfate solution
5. 5
   تجفيفThe ether solution was dried with MgSO4
6. 6
   أخرىevaporated to dryness in vacuo

الإجراء التجريبي

Samples of iodine (42.4 g, 0.167 mole) and silver acetate (27.87 g, 0.167 mole) were added in portions to a solution of 29.8 g (0.167 mole) of 1-(3-methoxyphenyl)butane-3-one in 167 ml of glacial acetic acid. The mixture was stirred one hour. The silver iodide was removed by filtration and washed with acetic acid. The filtrate was partitioned between ether and water. The ether layer was washed with water, sodium bicarbonate solution and sodium thiosulfate solution. The ether solution was dried with MgSO4 and evaporated to dryness in vacuo. There was obtained 41.8 g (82% yield) of oily 1-(2-iodo-5-methoxyphenyl)butane-3-one.

المصدر