تفاعل #43725

معادلة التفاعل

methyl chloroacetate

2-hydroxy-4-nitrobenzaldehyde

potassium carbonate

hydrochloric acid

potassium hydroxide

→

title compound

6-Nitro-1-benzofuran-2-carboxylic acid

المذيبات

water

THF

ظروف التفاعل

المعالجة

1. 1
   استخلاصThe mixture is extracted with ethyl acetate
2. 2
   غسيلThe organic phase is washed with water
3. 3
   تجفيفdried over sodium sulfate
4. 4
   workup.ADDITIONthe addition of silica gel
5. 5
   تركيزthe mixture is concentrated
6. 6
   أخرىchromatographed on silica gel (mobile phase gradient: toluene to toluene/methanol/glacial acetic acid 35:5:1)
7. 7
   أخرىConcentration of the product fractions and drying under reduced pressure

الإجراء التجريبي

5.8 g (34.7 mmol) of 2-hydroxy-4-nitrobenzaldehyde, 1.28 g (3.5 mmol) of tetra-N-butylammonium iodide and 19.2 g (138.8 mmol) of potassium carbonate are mixed, 7.9 g (72.9 mmol) of methyl chloroacetate are added and the mixture is heated at 130° C. for 12 h. 100 ml of THF and, with ice cooling, 11.7 g (208.2 mmol) of potassium hydroxide are added. Following the addition of 100 ml of water, the mixture is stirred at RT for 20 h. Using concentrated hydrochloric acid, the pH is adjusted to 0. The mixture is extracted with ethyl acetate. The organic phase is washed with water and dried over sodium sulfate. Following the addition of silica gel, the mixture is concentrated and chromatographed on silica gel (mobile phase gradient: toluene to toluene/methanol/glacial acetic acid 35:5:1). Concentration of the product fractions and drying under reduced pressure gives 1.31 g (18.2% of theory) of the title compound.

المصدر