تفاعل #43682

معادلة التفاعل

4-bromobenzo[b]thiophene

styrene

triethylamine

tris(2-methylphenyl)phosphine

→

title compound

4-[(E)-2-Phenylvinyl]benzo[b]thiophene

المذيبات

diethyl ether

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas refluxed overnight under an argon atmosphere
2. 2
   أخرىan insoluble material was removed by filtration
3. 3
   غسيلThe filtrate washed with 1 mol/L hydrochloric acid, water and brine successively
4. 4
   تجفيفdried over anhydrous magnesium sulfate
5. 5
   أخرىthe solvent was removed under reduced pressure
6. 6
   أخرىThe residue was purified by column chromatography on silica gel (eluent: n-hexane-n-hexane/ethyl acetate=5/1)

الإجراء التجريبي

A mixture of 4-bromobenzo[b]thiophene (0.55 g), styrene (0.89 mL), triethylamine (1.81 mL), palladium(II) acetate (59 mg) and tris(2-methylphenyl)phosphine (0.16 g) in acetonitrile (10 mL) was refluxed overnight under an argon atmosphere. The reaction mixture was diluted with diethyl ether and an insoluble material was removed by filtration. The filtrate washed with 1 mol/L hydrochloric acid, water and brine successively, and dried over anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: n-hexane-n-hexane/ethyl acetate=5/1) to give the title compound (0.56 g).

المصدر