تفاعل #436756

معادلة التفاعل

ethyl 3-(1-formyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)propanoate

ammonia

→

3-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)propanamide

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter evaporation of the solvent in vacuo
2. 2
   أخرىthe residue was triturated with diisopropyl alcohol
3. 3
   أخرىdried in vacuo

الإجراء التجريبي

A solution of ethyl 3-(1-formyl-2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)propanoate (10 g) in a mixture of methanol (50 ml) and an aqueous solution of 28% ammonia (104 ml) was stirred at room temperature for 41 hours. After evaporation of the solvent in vacuo, the residue was triturated with diisopropyl alcohol, dried in vacuo to give 3-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)propanamide (6.44 g).

المصدر