تفاعل #436754

معادلة التفاعل

2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide

triphenylmethyl chloride

→

2-(1-trityl-2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide

المردود 15.6%

المذيبات

pyridine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction mixture was evaporated under reduced pressure
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   تجفيفThe extract was dried over anhydrous magnesium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated in vacuo
6. 6
   أخرىThe residue was purified by column chromatography on silica gel eluting with ethyl acetate

الإجراء التجريبي

To a solution of 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide (1.67 g) in pyridine (15 ml) was added triphenylmethyl chloride (3.1 g) at room temperature. The mixture was stirred at 60° C. for 5.5 hours. The reaction mixture was evaporated under reduced pressure and extracted with ethyl acetate. The extract was dried over anhydrous magnesium sulfate, filtered, and concentrated in vacuo. The residue was purified by column chromatography on silica gel eluting with ethyl acetate to give 2-(1-trityl-2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylformamide (610 mg).

المصدر