تفاعل #436752

معادلة التفاعل

7-[(E)-2-nitroethenyl]-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1-carbaldehyde

lithium aluminum hydride

sodium fluoride

water

→

2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylamine

المردود 75.2%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooling
2. 2
   درجة الحرارةThe mixture was refluxed for 1.5 hours
3. 3
   درجة الحرارةAfter cooling on an ice bath
4. 4
   أخرىThe insoluble materials were removed by filtration
5. 5
   تركيزThe filtrate was concentrated in vacuo

الإجراء التجريبي

To a suspension of lithium aluminum hydride (465 mg) in tetrahydrofuran (10 ml) was added 7-[(E)-2-nitroethenyl]-2,3-dihydro-1H-imidazo[1,2-b]pyrazole-1-carbaldehyde (300 mg) under ice-cooling. The mixture was refluxed for 1.5 hours. After cooling on an ice bath, sodium fluoride (2.06 g) and water (0.882 ml) were added to the reaction mixture. The insoluble materials were removed by filtration. The filtrate was concentrated in vacuo to give 2-(2,3-dihydro-1H-imidazo[1,2-b]pyrazol-7-yl)ethylamine (165 mg). This product was used in the next step without further purification.

المصدر