تفاعل #43630

معادلة التفاعل

7-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2,3-dihydro-5(1H)-indolizinone

acetic acid

tetrabutylammonium fluoride

→

desired product

المردود 80.3%

7-(hydroxymethyl)-2,3-dihydro-5(1H)-indolizinone

المردود 80.3%

المذيبات

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىbefore being evaporated
2. 2
   أخرىThe residue was chromatographed on silica eluting with 0-20% methanol in dichloromethane

الإجراء التجريبي

A solution of 7-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2,3-dihydro-5(1H)-indolizinone (3.93 g, 14.09 mmol) in tetrahydrofuran (100 ml) was treated with acetic acid (1.61 ml, 28.17 mmol) and tetrabutylammonium fluoride (1M in THF, 21 ml, 21.13 mmol) and stirred at room temperature for 1 h before being evaporated. The residue was chromatographed on silica eluting with 0-20% methanol in dichloromethane to give the desired product (1.87 g, 80%)

المصدر