تفاعل #435283

معادلة التفاعل

2-methylthioethanol

sodium hydride

chloroacetic acid

hydrochloric acid

sodium chloride

→

title acid

المردود 69.5%

2-(2-(Methylthio)ethoxy)acetic acid

المردود 69.5%

المذيبات

tetrahydrofuran

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed twice with hexane) in dry tetrahydrofuran (250 ml) at 22° C
2. 2
   درجة الحرارةthe resulting mixture was then heated
3. 3
   درجة الحرارةunder reflux for 5 h
4. 4
   workup.ADDITIONadded to the aqueous phase until saturation
5. 5
   أخرىThe organic phase was separated
6. 6
   غسيلthe aqueous phase washed with ethyl acetate
7. 7
   غسيلThe combined organic extracts were washed with brine
8. 8
   تجفيفdried over anhydrous magnesium sulfate
9. 9
   تركيزconcentrated under reduced pressure
10. 10
    workup.DISTILLATIONDistillation of the resulting residue in vacuo

الإجراء التجريبي

A solution of 2-methylthioethanol (10.0 g, 0.108 mol) in dry tetrahydrofuran (25 ml) was added dropwise, over 30 min, to a suspension of sodium hydride (9.54 g of a 60% dispersion in mineral oil, 0.238 mol, washed twice with hexane) in dry tetrahydrofuran (250 ml) at 22° C. After 30 min, a solution of chloroacetic acid (10.25 g, 0.108 mol) in dry tetrahydrofuran (20 ml) was added dropwise, over 30 min at 22° C., and the resulting mixture was then heated under reflux for 5 h. The cooled mixture was treated with 250 ml of 1 N hydrochloric acid and sodium chloride added to the aqueous phase until saturation. The organic phase was separated and the aqueous phase washed with ethyl acetate. The combined organic extracts were washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. Distillation of the resulting residue in vacuo gave 11.27 g (69% yield) of the title acid as a clear oil; bp 85–95° C./0.3 torr (bulb to bulb distillation, air bath temperature). 1HNMR 400 MHz (CDCl3) δ ppm: 2.18 (3H, s, SCH3), 2.76 (2H, t, J=6.6 Hz, CH2), 3.77 (2H, t, J=6.6 Hz, CH2), 4.20 (2H, s, OCH2).

المصدر