تفاعل #43446

معادلة التفاعل

bromomaleic anhydride

Hydrazine sulphate salt

bromomaleic anhydride

hydrazine sulphate

→

4-bromo-1,2-dihydro-3,6-pyridazinedione

المردود 151.0%

المذيبات

water

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةheated
2. 2
   درجة الحرارةto reflux
3. 3
   درجة الحرارةThe mixture was heated
4. 4
   درجة الحرارةat reflux for 4 hours
5. 5
   ترشيحThe precipitates were collected by filtration
6. 6
   غسيلwashed with water and acetone
7. 7
   أخرىdried as a combined batch in vacuo

الإجراء التجريبي

Hydrazine sulphate salt (51 g) was suspended in water (250 ml), heated to reflux and bromomaleic anhydride (90.38 g) was added dropwise. The mixture was heated at reflux for 4 hours then cooled to room temperature. The reaction was repeated with 29 g hydrazine sulphate, 53 g bromomaleic anhydride and 130 ml water. The precipitates were collected by filtration, washed with water and acetone and dried as a combined batch in vacuo to afford 4-bromo-1,2-dihydro-3,6-pyridazinedione as a white solid (113 g).

المصدر