تفاعل #43436

معادلة التفاعل

{5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate

triethylsilane

trifluoroacetic acid

→

{5-Hydroxy-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate trifluoroacetate salt

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter 16 hours the mixture was evaporated
2. 2
   أخرىtriturated with toluene/ethyl acetate (250 ml/5 ml)
3. 3
   أخرىaffording a white solid
4. 4
   أخرىthat was isolated by filtration
5. 5
   أخرىdried in vacuo (22.5 g)

الإجراء التجريبي

A solution of {5-({[4-(methyloxy)phenyl]methyl}oxy)-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (26.3 g, 67 mmol) in dichloromethane (700 ml) was treated with triethylsilane (10 ml, 62.6 mmol)and trifluoroacetic acid (35 ml). After 16 hours the mixture was evaporated and triturated with toluene/ethyl acetate (250 ml/5 ml) affording a white solid that was isolated by filtration and dried in vacuo (22.5 g).

المصدر