تفاعل #433605

ord-3894a2dacea5405f82545427bd925ca1

معادلة التفاعل

CN(C)CC=CC(=O)Nc1ccc2ncnc(Nc3cccc(I)c3)c2c1
Compound 5
CN(C)CC=CC(=O)Nc1ccc2ncnc(Nc3cccc(I)c3)c2c1
N-{4-[(3-iodophenyl)amino]quinazoline-6-yl}-4-(dimethylamino)-2-butenamide
Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
4-[(3-bromophenyl)amino]-6-aminoquinazoline
C/C=C(\Br)C(=O)O
bromocrotonic acid
CNC
dimethylamine
CN(C)CC=CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1
N-{4-[(3-bromophenyl)amino]quinazoline-6-yl}4-(dimethylamino)-2-butenamide

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

4-[(3-bromophenyl)amino]-6-aminoquinazoline is reacted with bromocrotonic acid and dimethylamine, as is described hereinabove in Compound 5, to give N-{4-[(3-bromophenyl)amino]quinazoline-6-yl}4-(dimethylamino)-2-butenamide.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07172749B2uspto-grants-2007_02