تفاعل #433594

معادلة التفاعل

hydrazine hydrate

4-(phenylamino)-6-nitroquinazoline

iso-propylalcohol

→

4-(phenylamino)-6-aminoquinazoline

المذيبات

ethanol water

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction mixture is filtered
2. 2
   أخرىevaporated
3. 3
   أخرىpurified by silica gel chromatography

الإجراء التجريبي

A solution of 4-(phenylamino)-6-nitroquinazoline in ethanol/water and a polar solvent such as iso-propylalcohol is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel. The reaction mixture is filtered, evaporated and purified by silica gel chromatography, to give the product, 4-(phenylamino)-6-aminoquinazoline.

المصدر