تفاعل #43340

معادلة التفاعل

3,4-Dihydro-2H-pyran

pyridinium p-toluenesulfonate

chloroform

4-bromo-2-methoxyphenol

→

title compound

المردود 86.0%

2-(4-bromo-2-methoxyphenoxy)tetrahydro-2H-pyran

المردود 86.0%

المذيبات

brine

ظروف التفاعل

المعالجة

1. 1
   استخلاصfollowed by extraction with chloroform
2. 2
   غسيلThe organic layer was washed with water
3. 3
   تجفيفdried over anhydrous magnesium sulfate
4. 4
   تركيزConcentrating the solvent under reduced pressure
5. 5
   أخرىthe residue was purified on silica gel column chromatography (C-200; ethyl acetate:hexane=1:19)

الإجراء التجريبي

3,4-Dihydro-2H-pyran (2.0 mL) and pyridinium p-toluenesulfonate (370 mg) were added to chloroform solution (30 mL) of 4-bromo-2-methoxyphenol (3.0 g) and stirred at room temperature for 12 hours. Saturated brine was added to the reaction liquid, followed by extraction with chloroform. The organic layer was washed with water and dried over anhydrous magnesium sulfate. Concentrating the solvent under reduced pressure, the residue was purified on silica gel column chromatography (C-200; ethyl acetate:hexane=1:19) to provide the title compound (3.64 g, 86%).

المصدر