تفاعل #43332

معادلة التفاعل

Trifluoroacetic acid

4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one

→

title compound

المردود 92.7%

4-[(E)-2-(4-hydroxyphenyl)vinyl]-1-{4-[2-(1-pyrrolidinyl)-ethoxy]phenyl}-1H-pyridin-2-one

المردود 92.7%

ظروف التفاعل

المعالجة

1. 1
   تركيزAfter concentrating
2. 2
   أخرىthe reaction liquid under reduced pressure, chloroform
3. 3
   workup.ADDITIONwas added to the reaction liquid which
4. 4
   غسيلthen was washed with aqueous sodium hydrogencarbonate solution
5. 5
   تجفيفdried over anhydrous sodium sulfate
6. 6
   تركيزConcentrating the solvent under reduced pressure

الإجراء التجريبي

Trifluoroacetic acid (2 mL) was added to 4-((E)-2-{4-[(2-methyl-2-propyl)oxy]phenyl}vinyl)-1-{4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-1H-pyridin-2-one (120 mg, 0.26 mmol) and stirred at room temperature for 30 minutes. After concentrating the reaction liquid under reduced pressure, chloroform was added to the reaction liquid which then was washed with aqueous sodium hydrogencarbonate solution and dried over anhydrous sodium sulfate. Concentrating the solvent under reduced pressure, the title compound (97 mg, 92%) was obtained as a white solid.

المصدر