تفاعل #431260

ord-ae25054ff84d441eb72e798d8a6e39f6

معادلة التفاعل

CCCCc1nc2ccc(N(CCCC3CCCCC3)C(=O)NC)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1
tert.butyl 4'-[(2-n-butyl-6-(N-methylaminocarbonyl-N-(3-cyclohexyl-n-propyl)-amino)-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate
[Al+3].[Al+3].[O-2].[O-2].[O-2]
aluminium oxide
→
CCCCc1nc2ccc(OC(=O)NC3CCCCC3)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1
tert.butyl 4'-[(2-n-butyl-6-cyclohexylaminocarbonyloxy-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate

المتفاعلات

CCCCc1nc2ccc(N(CCCC3CCCCC3)C(=O)NC)cc2n1Cc1ccc(-c2ccccc2C(=O)OC(C)(C)C)cc1
tert.butyl 4'-[(2-n-butyl-6-(N-methylaminocarbonyl-N-(3-cyclohexyl-n-propyl)-amino)-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate
[Al+3].[Al+3].[O-2].[O-2].[O-2]
aluminium oxide
—
petroleum ether ethyl acetate

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

tert.butyl 4'-[(2-n-butyl-6-(N-methylaminocarbonyl-N-(3-cyclohexyl-n-propyl)-amino)-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylate oil, Rf value: 0.15 (aluminium oxide: petroleum ether/ethyl acetate=2:3)

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US05864043uspto-grants-1999_01