تفاعل #43041

معادلة التفاعل

Intermediate 11

N-[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-N-pyridin-2-ylmethyl-methanesulfonamide

tyramine

→

N-(3-{2-[2-(4-Hydroxy-phenyl)-ethylamino]-pyrimidin-4-yl}-benzyl)-N-pyridin-2-ylmethyl-methanesulfonamide

ظروف التفاعل

الإجراء التجريبي

Intermediate 11 was coupled with tyramine following procedure F. LC-MS showed the product had the expected M+H+ of 490. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) δ 8.6 (d, 1H) 8.3 (d, 1H) 7.9 (s, 2H) 7.6 (m, 1H) 7.4 (m, 2H) 7.3 (m, 2H) 7.2 (m, 1H) 7.0 (d, 2H) 6.9 (d, 1H) 6.7 (d, 2H) 5.5 (m, 1H) 4.5 (d, 4H) 3.7 (m, 2H) 3.0 (s, 3H) 2.9 (m, 2H).

المصدر