تفاعل #4303

معادلة التفاعل

Ether

benzyl 2-chloroethyl sulfone

isopropylamine

hydrogen chloride

→

white crystalline solid

المردود 65.8%

N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochloride

المردود 65.8%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed in vacuo
2. 2
   أخرىthe residue was partitioned between ether and dilute sodium hydroxide
3. 3
   تجفيفThe ether solution was dried over magnesium sulfate
4. 4
   أخرىthe solvent was removed in vacuo
5. 5
   أخرىto give an oil
6. 6
   أخرىa white solid precipitated

الإجراء التجريبي

A mixture of 51.49 g (0.236 mole) of benzyl 2-chloroethyl sulfone and 600 ml of isopropylamine was stirred at room temperature for 72 hr. The solvent was removed in vacuo, and the residue was partitioned between ether and dilute sodium hydroxide. The ether solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol, and excess ethereal hydrogen chloride was added. Ether was added, and a white solid precipitated to give 43.11 g (65.8%) of a white crystalline solid, m.p. 180.5°-181.5° C.

المصدر