تفاعل #430032

معادلة التفاعل

N-benzoyl-3,5-diacetylaniline

aminoguanidine hydrochloride

HCl

→

N-benzoyl-3,5-diacetylaniline bis(amidinohydrazone)dihydrochloride

المردود 97.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 18 hr
2. 2
   درجة الحرارةCooling
3. 3
   ترشيحfiltration

الإجراء التجريبي

Compound 26, FIG. 7E.26: A solution of 3,5-diacetylaniline (0.885 g) in tetrahydrofuran (10 mL) containing 0.45 mL pyridine was treated with 0.65 mL benzoyl chloride. The mixture was stirred 1 hr, then treated with 1 mL water and stirred 15 min. The mixture was then diluted with 40 mL water and stirred 30 min. Filtration and washing with water and isopropanol gave colorless needles of N-benzoyl-3,5-diacetylaniline, 1.36 g, mp 188°-189° C. A suspension of N-benzoyl-3,5-diacetylaniline (0.844 g) in aq. 87.5% ethanol (8 mL) containing 0.73 g aminoguanidine hydrochloride and a trace of HCl was heated at reflux for 18 hr. Cooling and filtration gave 1.357 g of N-benzoyl-3,5-diacetylaniline bis(amidinohydrazone)dihydrochloride (Compound 26), mp 268°-72° C.

المصدر