تفاعل #4300

معادلة التفاعل

ether

2-chloroethylphenylsulfone

phenethylamine

triethylamine

→

white crystalline solid

المردود 89.1%

N-[2-(Phenylsulfonyl)ethyl]benzeneethanamine, hydrochloride hemihydrate

المردود 89.1%

المذيبات

methanol

hydrogen chloride

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent was removed in vacuo
2. 2
   أخرىthe residue was partitioned between methylene chloride and dilute sodium hydroxide
3. 3
   تجفيفThe methylene chloride solution was dried over magnesium sulfate
4. 4
   أخرىthe solvent was removed in vacuo
5. 5
   أخرىto give an oil
6. 6
   workup.ADDITIONwas added
7. 7
   أخرىA white solid precipitated

الإجراء التجريبي

A mixture of 70.23 g (0.344 mole) of 2-chloroethylphenylsulfone, 41.92 g (0.343 mole) of phenethylamine and 60 ml of triethylamine in 800 ml of acetonitrile was stirred at room temperature for 18 hr. The solvent was removed in vacuo, and the residue was partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol and excess of ethereal hydrogen chloride was added and ether was added. A white solid precipitated to give 68.39 g (60%) of white crystalline solid, m.p. 194°-196° C.

المصدر