تفاعل #4297

معادلة التفاعل

2-chloroethylphenyl sulfone

methylamine

→

title compound

N-Methyl-2-(phenylsulfonyl)ethanamine

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvent is removed in vacuo
2. 2
   أخرىthe residue is partitioned between methylene chloride and dilute sodium hydroxide
3. 3
   استخلاصThe methylene chloride solution is extracted with dilute sulfuric acid
4. 4
   استخلاصThe acidic extract
5. 5
   استخلاصthe basic solution is extracted with methylene chloride
6. 6
   تجفيفThe methylene chloride solution is dried over magnesium sulfate
7. 7
   أخرىthe solvent is removed in vacuo

الإجراء التجريبي

A solution of 2-chloroethylphenyl sulfone and a large excess of methylamine (40% solution in water) in acetonitrile is stirred at room temperature overnight. The solvent is removed in vacuo and the residue is partitioned between methylene chloride and dilute sodium hydroxide. The methylene chloride solution is extracted with dilute sulfuric acid. The acidic extract is made basic with 50% sodium hydroxide and the basic solution is extracted with methylene chloride. The methylene chloride solution is dried over magnesium sulfate and the solvent is removed in vacuo to give the title compound.

المصدر