تفاعل #4294

معادلة التفاعل

2-chloroethylphenylsulfone

potassium phthalimide

→

2-[2-(Phenylsulfonyl)ethyl]-1H-isoindole-1,3-(2H)-dione

المردود 35.7%

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىthe residue was partitioned between water and chloroform
2. 2
   تجفيفThe chloroform layer was dried
3. 3
   ترشيحfiltered
4. 4
   أخرىsolvent was evaporated from the filtrate
5. 5
   أخرىto give an oil which
6. 6
   أخرىcrystallized
7. 7
   أخرىThe solid was triturated with isopropyl ether
8. 8
   درجة الحرارةthe mixture cooled under refrigeration
9. 9
   ترشيحThe solid was collected by filtration
10. 10
    أخرىdried
11. 11
    أخرىrecrystallized from methanol-isopropyl ether
12. 12
    أخرىto give white crystalline product, m.p. 186°-188° C.

الإجراء التجريبي

A solution of 30.7 g (0.15 mole) of 2-chloroethylphenylsulfone and 69.5 g (0.375 mole) of potassium phthalimide in 600 ml of dimethylformamide was heated overnight at 85° C. The reaction mixture was stripped to dryness and the residue was partitioned between water and chloroform. The chloroform layer was dried and filtered and solvent was evaporated from the filtrate to give an oil which crystallized on standing. The solid was triturated with isopropyl ether and the mixture cooled under refrigeration. The solid was collected by filtration and dried and recrystallized from methanol-isopropyl ether to give white crystalline product, m.p. 186°-188° C., in 35.7% yield.

المصدر