تفاعل #42895

ord-d2b7ab22b54244d1aaa331dd8619542f

معادلة التفاعل

COC(=O)c1cscc1NC(=O)C(F)Cl
4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester
CC(C)(C)c1ccc(O)cc1
4-tert-butylphenol
→
CC(C)(C)c1ccc(OC(F)C(=O)Nc2cscc2C(=O)O)cc1
title compound
CC(C)(C)c1ccc(OC(F)C(=O)Nc2cscc2C(=O)O)cc1
Rac-4-[2-(4-tert-Butyl-phenoxy)-2-fluoro-acetylamino]-thiophene-3-carboxylic acid

المتفاعلات

COC(=O)c1cscc1NC(=O)C(F)Cl
4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester
CC(C)(C)c1ccc(O)cc1
4-tert-butylphenol

الكواشف

لا شيء

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

الإجراء التجريبي

In analogy to Example 58, the title compound was prepared using 4-(2-chloro-2-fluoro-acetylamino)-thiophene-3-carboxylic acid methyl ester and 4-tert-butylphenol. MS (m/e): 350.3 (M−H).

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07732452B2uspto-grants-2010_06