تفاعل #42863

معادلة التفاعل

4,5,6-trifluoropyrimidine

3,5-dimethylpiperidine

→

4,5-difluoro-6-(3,5-dimethylpiperidino)pyrimidine

المردود 97.9%

المذيبات

toluene

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىhalf hour

الإجراء التجريبي

Into 6 ml of toluene solution of 0.5 g of 4,5,6-trifluoropyrimidine was added dropwise 1 ml toluene solution of 0.51 g of 3,5-dimethylpiperidine (cis/trans diastereomer=about 4/1) at 0° C., and the mixture was stirred for one-and-half hour at same temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.83 g of 4,5-difluoro-6-(3,5-dimethylpiperidino)pyrimidine. This compound had the cis/trans diastereomers originated two methyls on the piperidine ring. The ratio of the cis/trans diastereomer was about 5/1.

المصدر