تفاعل #42862

معادلة التفاعل

4,6-dichloro-5-fluoropyrimidine

cis-2,6-dimethylpiperidine

→

4-chloro-6-(cis-2,6-dimethylpiperidino)-5-fluoropyrimidine

المردود 57.5%

ظروف التفاعل

الإجراء التجريبي

0.25 g of 4,6-dichloro-5-fluoropyrimidine and 0.34 g of cis-2,6-dimethylpiperidine were mixed and stirred for 11 hours at 70° C. The reaction mixture was subjected to silica gel column chromatography to obtain 0.21 g of 4-chloro-6-(cis-2,6-dimethylpiperidino)-5-fluoropyrimidine.

المصدر