تفاعل #42860

معادلة التفاعل

4,6-dichloro-5-fluoropyrimidine

2-ethylhexahydro-1H-azepine

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1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine

المردود 97.2%

ظروف التفاعل

الإجراء التجريبي

0.4 g of 4,6-dichloro-5-fluoropyrimidine and 0.61 g of 2-ethylhexahydro-1H-azepine were mixed and left for 1 hour at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.6 g of 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine.

المصدر