تفاعل #428328

معادلة التفاعل

1-bromo-3-fluoropropane

117

(4-bromo-benzyl)-carbamic acid tert-butyl ester

sodium hydride

→

(4-bromo-benzyl)-(3-fluoro-propyl)-carbamic acid tert-butyl ester

المردود 46.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   أخرىThe reaction mixture was then quenched with water (10 mL)
3. 3
   استخلاصthe resulting aqueous solution was extracted with EtOAc (2×20 mL)
4. 4
   غسيلThe combined organic extracts were washed with water (10 mL) and saturated aqueous NaCl (10 mL)
5. 5
   تجفيفdried over MgSO4
6. 6
   تركيزconcentrated in vacuo
7. 7
   أخرىThe residue was purified by column chromatography (10-15% EtOAc/hexane gradient elution)

الإجراء التجريبي

To a solution of 117 (286 mg, 1.0 mmol) in anhydrous DMF (3.0 mL) was added sodium hydride (NaH, 60% oil dispersion, 48.0 mg, 1.2 mmol, 1.2 equiv) at 0° C. The resulting mixture was stirred at 0° C. for 30 min before 1-bromo-3-fluoropropane 118 (170 mg, 1.2 mmol, 1.2 equiv) was added. The reaction mixture was subsequently warmed to 50-60° C. and stirred for 24 hours. The reaction mixture was then quenched with water (10 mL), and the resulting aqueous solution was extracted with EtOAc (2×20 mL). The combined organic extracts were washed with water (10 mL) and saturated aqueous NaCl (10 mL), dried over MgSO4 and concentrated in vacuo. The residue was purified by column chromatography (10-15% EtOAc/hexane gradient elution) to afford the desired (4-bromo-benzyl)-(3-fluoro-propyl)-carbamic acid tert-butyl ester 115 (158 mg, 46% yield) as a colorless oil.

المصدر