تفاعل #42727

معادلة التفاعل

4-hydroxyphenethyl alcohol

potassium carbonate

1,3 dibromopropane

→

title compound

المردود 77.3%

2-[4-(3-Bromopropoxy)phenyl]ethanol

المردود 77.3%

المذيبات

acetonitrile

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةcooled to room temperature
2. 2
   ترشيحfiltered
3. 3
   تركيزconcentrated under vacuum
4. 4
   أخرىThe resulting oil was purified by silica gel chromatography
5. 5
   workup.ADDITIONa mixture of 4:1 hexanes and ethyl acetate

الإجراء التجريبي

To a solution of 4-hydroxyphenethyl alcohol (4.37 g, 31.0 mmol) and potassium carbonate (6.55 g, 47.0 mmol) in acetonitrile (62.0 mL) was added 1,3 dibromopropane (31.0 mL, 316 mmol). The reaction mixture was heated to 70° C. for 12 hours and then cooled to room temperature, filtered and concentrated under vacuum. The resulting oil was purified by silica gel chromatography using a mixture of 4:1 hexanes and ethyl acetate to give the title compound (6.21 g) as a white solid.

المصدر