تفاعل #42560

معادلة التفاعل

[1-(3,5-difluorobenzyl)-3-[1-(3-ethynylphenyl)cyclopropylamino]-2-hydroxypropyl]-carbamic acid tert-butyl ester

HCl

dioxane

methanol

→

solid

المردود 106.0%

BOC-acetylene

المردود 106.0%

ظروف التفاعل

المعالجة

1. 1
   أخرىThe volatiles were evaporated in vacuo
2. 2
   workup.ADDITIONDioxane (20 mL) was added
3. 3
   أخرىthe mixture was evaporated in vacuo

الإجراء التجريبي

[1-(3,5-difluorobenzyl)-3-[1-(3-ethynylphenyl)cyclopropylamino]-2-hydroxypropyl]-carbamic acid tert-butyl ester (2.34 g, 5.13 mmol) was treated with 4N HCl in dioxane (15.8 mL, 63.3. mmol). The resulting heterogeneous mixture was treated with methanol (10 mL) whereupon it became homogeneous over 30 min. The volatiles were evaporated in vacuo. Dioxane (20 mL) was added and the mixture was evaporated in vacuo to produce a white solid (2.33 g, 106%).

المصدر