تفاعل #425211

معادلة التفاعل

(1R,2R)-1-(1-methyl-1H-pyrazol-5-yl)cyclohexane-1,2-diol

dimethylaminopyridine

carbonyldiimidazole

→

title compound

المردود 92.0%

(3aR,7aR)-3a-(1-Methyl-1H-pyrazol-5-yl)hexahydro-1,3-benzodioxol-2-one

المردود 92.0%

المذيبات

toluene

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction and aftertreatment

الإجراء التجريبي

The reaction and aftertreatment were conducted in the same manner as in Example 167a by using the (1R,2R)-1-(1-methyl-1H-pyrazol-5-yl)cyclohexane-1,2-diol (1.21 g, 6.17 mmol) prepared in Example 168a, dimethylaminopyridine (75.3 mg, 0.62 mmol), carbonyldiimidazole (3.50 g, 21.6 mmol) and toluene (20 mL), to yield the title compound (1.26 g, 92%) as a colorless oil.

المصدر