تفاعل #425208

معادلة التفاعل

(3aS,7aS)-3a-(1-methyl-1H-pyrazol-5-yl)hexahydro-1,3-benzodioxol-2-one

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title compound

المردود 21.0%

(1S,2S)-2-(1-Methyl-1H-pyrazol-5-yl)cyclohexanol

المردود 21.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction solution was filtered through celite
2. 2
   أخرىthe residue was purified with silica gel chromatography (hexane/ethyl acetate=2:1)

الإجراء التجريبي

A solution of the (3aS,7aS)-3a-(1-methyl-1H-pyrazol-5-yl)hexahydro-1,3-benzodioxol-2-one (500 mg, 2.25 mmol) prepared in Example 167a and palladium carbon (10%; 500 mg) in THF (10 mL) was stirred at 60° C. for 12 hours under a hydrogen atmosphere. The reaction solution was filtered through celite, and the residue was purified with silica gel chromatography (hexane/ethyl acetate=2:1) to yield the title compound (85 mg, 21%) as a colorless oil.

المصدر