تفاعل #42504

معادلة التفاعل

Butyl 1-butyl-3-(trifluoroacetyl)-1H-indole-6-carboxylate

LiOH.H2O

THF

water

→

1-butyl-3-(trifluoroacetyl)-1H-indole-6-carboxylic acid

المردود 70.7%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solvents were then removed under reduced pressure and HCl (2N, 0.5 mL)
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   استخلاصThe residue was extracted with ethyl acetate
4. 4
   تجفيفdried over magnesium sulfate
5. 5
   ترشيحfiltered
6. 6
   تركيزconcentrated

الإجراء التجريبي

Butyl 1-butyl-3-(trifluoroacetyl)-1H-indole-6-carboxylate (0.277 g), LiOH.H2O (0.040 g), THF (1.5 mL), water (0.5 mL), and methanol (0.5 mL) were stirred overnight at room temperature. The solvents were then removed under reduced pressure and HCl (2N, 0.5 mL) was added to the residue. The residue was extracted with ethyl acetate, dried over magnesium sulfate, filtered, and concentrated. Chromatography on silica gel using methanol/dichloromethane (6/94) gave 1-butyl-3-(trifluoroacetyl)-1H-indole-6-carboxylic acid (0.166 g). MS (ESI+) for C15H14F3N1O3+H1 m/z 314.10 (M+H)+.

المصدر