تفاعل #42499

معادلة التفاعل

Methyl 1H-indole-6-carboxylate

potassium tert-butoxide

Iodobutane

→

methyl 1-butyl-1H-indole-6-carboxylate

المذيبات

DMSO

ظروف التفاعل

المعالجة

1. 1
   workup.STIRRINGto stir for three additional hours
2. 2
   أخرىThe mixture was partitioned between ethyl acetate and water and brine
3. 3
   تجفيفdried over sodium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated

الإجراء التجريبي

Methyl 1H-indole-6-carboxylate (4.17 g) was dissolved in DMSO (30 mL), and potassium tert-butoxide (2.93 g) was added. The mixture was stirred for ten min at room temperature. Iodobutane (3.0 mL) was added. The mixture was allowed to stir for three additional hours. The mixture was partitioned between ethyl acetate and water and brine, dried over sodium sulfate, filtered, and concentrated to give methyl 1-butyl-1H-indole-6-carboxylate (4.53 g). MS (ESI+) for C14H17NO2+H1 m/z 232.12 (M+H)+.

المصدر