تفاعل #424445

معادلة التفاعل

Ethyl 3-hydroxy-2-methylbenzoate

K2CO3

2,6-Dimethylbenzyl chloride

→

title compound

Ethyl 3-(2,6-dimethylbenzyloxy)-2-methylbenzoate

المذيبات

DMF

EtOAc

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water (20 ml) and brine
2. 2
   تجفيفThe organic layer was dried over Na2SO4
3. 3
   ترشيحfiltered
4. 4
   تركيزconcentrated
5. 5
   أخرىpurified by flash chromatography on a silica gel column (hex: ethyl acetate 4:1)

الإجراء التجريبي

To a stirred solution of Ethyl 3-hydroxy-2-methylbenzoate (Step A, 3.1 g, 17.22 mmol), K2CO3 (3.09 g, 22.38 mmol) in dry DMF (15 ml) was added 2,6-Dimethylbenzyl chloride (3.19 g, 20.66 mmol) at room temperature under argon. The reaction mixture was stirred for 16 hours, diluted with EtOAc (40 ml), washed with water (20 ml) and brine. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex: ethyl acetate 4:1) to give the title compound as a white solid.

المصدر