تفاعل #42410

معادلة التفاعل

sodium borohydride

N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxoindane-5-carboxamide

SP-201

→

title compound

N-{(1S,2R)-1-(3,5-Difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-hydroxyindane-5-carboxamide

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction is concentrated under reduced pressure
2. 2
   workup.DISSOLUTIONredissolved in water (3 mL)
3. 3
   أخرىpartitioned into ethyl acetate
4. 4
   غسيلThe organic layer is washed with water, saturated sodium bicarbonate, and brine
5. 5
   تجفيفdried (sodium sulfate)
6. 6
   ترشيحfiltered
7. 7
   تركيزconcentrated under reduced pressure

الإجراء التجريبي

To an ice-cold solution of N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]-2-hydroxypropyl}-3-oxoindane-5-carboxamide prepared by the method in Example SP-201 (66 mg, 0.13 mmol) in methanol (3 mL) is added sodium borohydride (20 mg, 0.52 mmol). The reaction stirred at room temperature 3 h. The reaction is concentrated under reduced pressure, redissolved in water (3 mL) and partitioned into ethyl acetate. The organic layer is washed with water, saturated sodium bicarbonate, and brine, dried (sodium sulfate), filtered, and concentrated under reduced pressure to give the title compound. ESI MS m/z 495.2 [M+H]+.

المصدر