تفاعل #423771

معادلة التفاعل

3-Bromo-2-methylphenol

1-bromoadamantane

hexamethylphosphoramide

→

title compound

1-(3-bromo-2-methylphenoxy)tricyclo[3.3.1.13,7]decane

المذيبات

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water two times
2. 2
   غسيلwashed with brine
3. 3
   تجفيفdried on anhydrous sodium sulfate
4. 4
   ترشيحfiltered
5. 5
   تركيزconcentrated
6. 6
   أخرىThe crude material was purified by flash column chromatography on silica gel using 2% ethyl acetate (hexanes)
7. 7
   درجة الحرارةincreasing to 5% ethyl acetate (hexanes)

الإجراء التجريبي

3-Bromo-2-methylphenol (1000 mg) and 1-bromoadamantane (2013 mg) were added to hexamethylphosphoramide (8 mL) and the mixture was heated in a microwave reactor (Biotage) at 250° C. for 35 minutes. The solution was taken up in diethyl ether, washed with water two times, washed with brine, dried on anhydrous sodium sulfate, filtered, and concentrated. The crude material was purified by flash column chromatography on silica gel using 2% ethyl acetate (hexanes) increasing to 5% ethyl acetate (hexanes) to yield the title compound.

المصدر