تفاعل #423770

معادلة التفاعل

2-fluoro-4-iodo-3-methylpyridine

1-Hydroxylmethyladamantane

NaH

→

title compound

2-(tricyclo[3.3.1.13,7]dec-1-ylmethoxy)-4-iodo-3-methyl-pyridine

المذيبات

tetrahydrofuran

tetrahydrofuran

ظروف التفاعل

المعالجة

1. 1
   أخرىquenched with H2O
2. 2
   استخلاصextracted with ethyl acetate
3. 3
   غسيلThe combined organic layers were washed with brine
4. 4
   تركيزconcentrated
5. 5
   أخرىThe residue was purified by preparative TLC
6. 6
   غسيلeluting with petroleum ether

الإجراء التجريبي

1-Hydroxylmethyladamantane (249 mg) was dissolved in tetrahydrofuran (3.5 mL) and NaH (24 mg) was added. After the gas evolution ceased, 2-fluoro-4-iodo-3-methylpyridine (237 mg) in tetrahydrofuran (1.5 mL) was added. The reaction mixture was stirred at room temperature for 0.5 hours, quenched with H2O and extracted with ethyl acetate. The combined organic layers were washed with brine and concentrated. The residue was purified by preparative TLC, eluting with petroleum ether to provide the title compound.

المصدر