تفاعل #42355

معادلة التفاعل

O-benzyl-N-(tert-butoxycarbonyl)homoserine

trimethylsilyldiazomethane

hexane

→

title compound

Methyl O-benzyl-N-(tert-butoxycarbonyl)homoserinate

المذيبات

methanol benzene

ظروف التفاعل

المعالجة

1. 1
   تركيزThe solution is concentrated under reduced pressure

الإجراء التجريبي

To O-benzyl-N-(tert-butoxycarbonyl)homoserine (5.8 g, 18.9 mmol) in 20% methanol/benzene (72 mL) is added 2M trimethylsilyldiazomethane in hexane (12.3 mL, 24.5 mmol), and the reaction stirred at room temperature 1.5 h. The solution is concentrated under reduced pressure to give the title compound in pure form. ESI MS m/z 324.2 [M+H]+.

المصدر