تفاعل #423184

معادلة التفاعل

(S)-7-bromo-3-chloro-1-fluoro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine

2-fluoropyridin-3-ylboronic acid

4,4-difluoropiperidine hydrochloride

→

title compound

(S)-3-(4,4-difluoropyrrolidin-1-yl)-1-fluoro-7-(2-fluoropyridin-3-yl)-5′-H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine

ظروف التفاعل

المعالجة

1. 1
   أخرىprepared by steps analogous to

الإجراء التجريبي

The title compound was synthesized by steps analogous to those described in method CC4 above, but using (S)-7-bromo-3-chloro-1-fluoro-5′H-spiro[chromeno[2,3-c]pyridine-5,4′-oxazol]-2′-amine (prepared by steps analogous to those described in Method BB33), 2-fluoropyridin-3-ylboronic acid and 4,4-difluoropiperidine hydrochloride.

المصدر