تفاعل #42273

معادلة التفاعل

Water

sodium hydroxide

methyl 3-(aminocarbonyl)-5-[(dipropylamino)carbonyl]benzoate

Methyl 3-(aminocarbonyl)-5-[(dipropylamino)carbonyl]-benzoate

hydrochloric acid

→

title compound

3-(Aminocarbonyl)-5-[(dipropylamino)carbonyl]benzoic acid

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   غسيلthe mixture is washed twice with ethyl acetate (2×50 mL)
2. 2
   تجفيفdried over anhydrous magnesium sulfate
3. 3
   تركيزconcentrated

الإجراء التجريبي

To a mixture of methyl 3-(aminocarbonyl)-5-[(dipropylamino)carbonyl]benzoate (XXII, PREPARATION 5, 0.197 g, 0.64 mmol) in methanol (5.0 mL) is added sodium hydroxide (1N, 3.0 mL). The mixture is stirred at 20-25 degrees C. for 24 hours. The mixture is acidified to about pH 5 with hydrochloric acid (10%). Water (50 mL) is added and the mixture is washed twice with ethyl acetate (2×50 mL). The organic extracts are combined and dried over anhydrous magnesium sulfate and concentrated to give the title compound, NMR (DMSO-d6) delta 0.66, 0.930, 1.48, 1.62, 3.12, 3.35, 7.54, 7.98, 8.22 and 8.51.

المصدر