تفاعل #4209

معادلة التفاعل

2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

sodium iodide

→

title compound

المردود 60.4%

2-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

المردود 60.4%

المذيبات

acetone

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe reaction was filtered hot
2. 2
   أخرىto remove the sodium iodide
3. 3
   أخرىa precipitate formed in the cold filtrate which
4. 4
   أخرىwas collected
5. 5
   غسيلwashed with cold acetone
6. 6
   أخرىto give
7. 7
   أخرىupon drying

الإجراء التجريبي

A solution of 2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide (8.98 g, 23.5 mmol) and sodium iodide (3.53 g, 23.5 mmol) in acetone (75 ml) was refluxed for two hours and allowed to stand overnight at room temperature. The reaction was filtered hot to remove the sodium iodide and a precipitate formed in the cold filtrate which was collected and washed with cold acetone to give, upon drying, 6.71 g (14.2 mmol) of the title compound. A second crop was obtained from cold acetone (1.0 g).

المصدر