تفاعل #42036

معادلة التفاعل

4-(1-methylpiperidin-4-ylidenemethyl)-3-trifluoromethylbenzoic acid

thionyl chloride

→

4-(1-methylpiperidin-4-ylidenemethyl)-3-trifluoromethylbenzoyl chloride hydrochloride

ظروف التفاعل

المعالجة

1. 1
   أخرىobtained in the step 3
2. 2
   workup.DISTILLATIONwas distilled off under reduced pressure
3. 3
   workup.ADDITIONthe operation of adding of toluene to the residue
4. 4
   أخرىfollowed by azeotropic removal of thionyl chloride

الإجراء التجريبي

This compound was prepared in the same manner as in Reference Example 1 (step 7), except that 4-(1-methylpiperidin-4-ylidenemethyl)-3-trifluoromethylbenzoic acid obtained in the step 3 was used, and that treatment after the reaction was that thionyl chloride was distilled off under reduced pressure, and then the operation of adding of toluene to the residue, followed by azeotropic removal of thionyl chloride was repeated three times.

المصدر