تفاعل #419443

معادلة التفاعل

6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

4,4-difluoropiperidine hydrochloride

→

title compound

المردود 98.0%

(4,4-Difluoro-piperidin-1-yl)-[6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-pyridin-3-yl]-methanone

المردود 98.0%

ظروف التفاعل

الإجراء التجريبي

As described for example 8b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using 4,4-difluoropiperidine hydrochloride (1 M in DMF) instead of methylamine, to the title compound (131 mg, 98%) which was obtained as a light yellow gum. MS: m/e=414.4 [M+H]+.

المصدر