تفاعل #41806

معادلة التفاعل

1

2-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine

methoxylamine HCl

pyridine

→

2

3-Fluoro-4-(4-methyl-piperazin-1-yl)-benzene-1,2-diamine

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe resulting reaction mixture
2. 2
   تركيزThe crude product was concentrated
3. 3
   أخرىabsorbed onto silica gel
4. 4
   أخرىpurified by flash chromatography (97:3 CH2Cl2/MeOH)

الإجراء التجريبي

A 25 mL round bottom flask was charged with a suspension of 1 (600 mg, 2.2 mmol), methoxylamine HCl (202 mg, 2.42 mmol), and pyridine (0.22 mL, 2.6 mmol) in ethanol (9 mL). The resulting reaction mixture was stirred at rt overnight. The crude product was concentrated, absorbed onto silica gel, and purified by flash chromatography (97:3 CH2Cl2/MeOH) to give 2 as an orange solid. LCMS m/z 303.2 (MH+), tR=2.40 mm.

المصدر