تفاعل #417972

معادلة التفاعل

Water

compound 26a

2-(3-bromo-propoxy)-1-chloro-4-nitro benzene

N-phenyl piperazine

potassium carbonate

→

title compound 26b

المردود 78.0%

1-[3-(2-chloro-5-nitro-phenoxy)-propyl]-4-phenyl-piperazine

المردود 78.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىat room temperature
2. 2
   استخلاصextracted with ethyl acetate (3×20 mL)
3. 3
   تجفيفThe combined extracts were dried over sodium sulfate
4. 4
   تركيزconcentrated under reduced pressure
5. 5
   أخرىThe crude product was purified by flash column chromatography

الإجراء التجريبي

To the compound 26a (2.1 g, 7.1 mmol) in DMF (9 mL) was added N-phenyl piperazine (1.16 g, 7.1 mmol) and potassium carbonate (1.28 g, 9.23 mmol). The mixture was stirred for 18 hrs. at room temperature. Water (10 mL) was added to the reaction mixture and extracted with ethyl acetate (3×20 mL). The combined extracts were dried over sodium sulfate and concentrated under reduced pressure. The crude product was purified by flash column chromatography to get the title compound 26b in 78% yield as yellow solid.

المصدر